The role of Dopamine in Preparatory Inhibition: What can we learn from Parkinson’s disease?

Wilhelm, Emmanuelle;Quoilin, Caroline;Derosiere, Gérard;Jeanjean, Anne;Duque, Julie
(2018) Belgian Brain Congress 2018 — Location: Liège (19.October.2018)

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Abstract
Recent transcranial magnetic stimulation studies have shown that the motor output pathway shows a profound inhibition during the preparation of an action. This phenomenon, called “preparatory inhibition”, remains incompletely understood, as it is still unclear which neural structures support it and what function it exactly serves during action preparation. In the current study, we tested this preparatory inhibition in Parkinson’s disease (PD) patients and matched healthy control subjects. The aim was to better understand the role of basal ganglia (which are dysfunctional in PD) and the influence of dopamine replacement therapy on motor inhibition during action preparation.
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Wilhelm, E., Quoilin, C., Derosiere, G., Jeanjean, A., & Duque, J. (2018). The role of Dopamine in Preparatory Inhibition: What can we learn from Parkinson’s disease? Front. Neurosci. Belgian Brain Congress 2018, 1(1), 1. https://doi.org/10.3389/conf.fnins.2018.95.00087 (Original work published 2018)