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Authors
  • Poljanic, LeonUCLouvain
    Author
  • Leyssens, TomUCLouvain
    Author
  • Collard, LaurentUCLouvain
    Author
  • Baier, Daniel Morcid-logoDepartment of Molecular Chemistry, Materials and Catalysis, Institute of Condensed Matter and Nanosciences, Université Catholique de Louvain, Place Louis Pasteur 1, 1348 Louvain-la-Neuve, Belgium
    Author
Abstract
We investigated the stereochemical stability of biaryl atropisomers under conditions typically employed in organic mechanosynthesis. Systematic variation of reaction parameters revealed three degradation pathways: racemisation, cyclisation, and oligomerisation. This previously overlooked behaviour critically impacts catalytic performance in asymmetric synthesis, highlighting the need for rigorous stability assessment during mechanochemical reactions.
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Poljanic, L., Leyssens, T., Collard, L., & Baier, D. M. (2026). When chirality breaks: mechanochemical degradation of biaryl atropisomers. RSC Mechanochemistry, 3(2), 218-223. https://doi.org/10.1039/d5mr00132c (Original work published 2026)