Design, development and validation of a novel ionization chamber for emerging hadron therapy modalities : FLASH proton therapy and carbon ion therapy
(2025)
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- Abstract
- High-LET particle therapy and FLASH radiotherapy offer promising strategies to improve tumor control and reduce normal-tissue toxicity, yet they introduce major dosimetric challenges due to high ionization densities. Under these conditions, ionization chambers experience significant ion recombination, making current correction methods complex and sometimes unreliable. This thesis addresses these limitations through the development of a novel dual-gap ionization chamber (DGIC) for reference dosimetry. A Monte Carlo simulation was developed to investigate recombination losses under realistic beam conditions, guiding chamber design. Experimental studies assessed the radiation tolerance of materials under prolonged ultra-high dose rates irradiation. Based on these insights, a DGIC prototype was developed and tested across multiple beams. Its inherent method is able to obtain recombination correction factors from a single irradiation, enabling a more efficient dosimetric workflow.
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Citations
Orts Sanz, M. (2025). Design, development and validation of a novel ionization chamber for emerging hadron therapy modalities : FLASH proton therapy and carbon ion therapy.