Structural Elucidation and Cytotoxicity of a New 17-Membered Ring Lactone from Algerian .
(2018) Molecules — Vol. 23, n° 12, p. 3250 [1-14] (2018)
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Beaufay, Claire 
- Abstract
- The chemical composition of a hexanic extract of , obtained from its aerial parts, was investigated by GC-FID, GC/MS, HRMS, NMR and VCD analyses. The main compounds were germacrene D (23.6%), eudesma-4(15)-7-dien-1-β-ol (8.2%) and falcarindiol (9.4%), which are associated with a new uncommon and naturally found 17-membered ring lactone. This 17-membered ring features conjugated acetylenic bonds, named campestrolide (23.0%). The crude extract showed moderate antitrypanosomal (), antileishmanial () and anticancer (cancerous macrophage-like murine cells) activities, and also displayed cytotoxicity, (human normal fibroblasts) in similar concentration ranges (IC = 3.0, 3.9, 4.0 and 4.4 µg/mL respectively). Likewise, campestrolide displayed low activity on all tested cells (IC: 12.5⁻19.5 µM) except on , on which it was very active and moderately selective (IC = 2.2 µM. SI= 8.9). In conclusion, the new compound that has been described, displaying a singular structure, possesses interesting antitrypanosomal activity that should be further investigated and improved.
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Medbouhi, A., Tintaru, A., Beaufay, C., Naubron, J.-V., Djabou, N., Costa, J., Quetin-Leclercq, J., & Muselli, A. (2018). Structural Elucidation and Cytotoxicity of a New 17-Membered Ring Lactone from Algerian . Molecules, 23(12), 3250 [1-14]. https://doi.org/10.3390/molecules23123250 (Original work published 2018)