Modulating hypoxia and oxidative stress in human ovarian tissue xenografts using adipose tissue-derived stem cells
(2021) ESHRE virtual Meeting 2021 — Location: Virtual (26.June.2021)
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- Abstract
- Study question: To investigate whether adipose tissue-derived stem cells (ASCs) modulate hypoxia and oxidative stress in human ovarian tissue transplants to reduce early follicle loss. Summary answer: ASCs protect the follicle pool by mitigating the hypoxia-related response through HIF1α signaling in human xenografts and enhancing revascularization by ensuring faster tissue reperfusion. What is known already: ASCs are known for their angiogenic potential and capacity to boost angiogenesis by secreting growth factors and differentiating into vessels in numerous models of wound healing in regenerative medicine. In a 2-step ovarian tissue xenotransplantation involving grafting inside a fibrin scaffold two weeks prior to transplantation, ASCs reduced follicle loss after short- and long-term grafting, as well as abnormal follicle activation, by increasing reoxygenation and revascularization in human xenografts.
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Citations
Cacciottola, L., Nguyen, T. Y. T., Andrade Amorim, C., Donnez, J., & Dolmans, M.-M. (2021). Modulating hypoxia and oxidative stress in human ovarian tissue xenografts using adipose tissue-derived stem cells. ESHRE virtual Meeting 2021, Virtual. https://hdl.handle.net/2078.5/109169