Altered pIgR/IgA mucosal immunity in bronchiolitis obliterans syndrome
(2022) ERS International Congress 2022 — Location: Barcelona (4.September.2022)
Files
CARLIERFM-AbstractERS2022BOSIGA_final.docx
Open Access - Microsoft Word XML
- 29.79 KB
Details
- Authors
- Abstract
- Aims: Long-term survival after lung transplantation (LT) is hampered by the occurrence of chronic lung allograft dysfunction (CLAD), manifesting as bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS). CLAD is triggered by several factors, e.g. recurrent infections. As immunoglobulin (Ig) A is crucial to ensure mucosal immunity and limit airway microbial load, we explored whether IgA and its epithelial receptor, the polymeric Ig receptor (pIgR) are impaired in BOS. Methods: Bronchoalveolar lavages (BAL, n=120) from LT recipients included in the Cohort for Lung Transplantation were collected at pre-defined timepoints prior to the diagnosis of functional stability (BOS-free, n=30) or BOS (pre-BOS, n=30), and assessed for secretory (S)-IgA. Bronchiolar epithelium pIgR expression was quantified in transbronchial biopsies from BOS-free (n=20), pre-BOS (n=19) and BOS LT recipients (n=12), as well as in end-stage BOS explants (n=15). Results: S-IgA levels were reduced in BAL from pre-BOS LT recipients versus BOS-free (16.1 vs 33.4 µg/ml, p<0.01). pIgR bronchiolar expression was reduced in transbronchial biopsies from BOS (p<0.05 vs BOS-free and pre-BOS), with further decrease in end-stage BOS explants (p<0.0001 vs BOS-free and pre-BOS). Conclusions: BAL S-IgA and pIgR decreased levels suggest that the pIgR/IgA system is impaired in BOS. This could play a pathogenic role by increasing susceptibility to local infections.
- Affiliations
Citations
Carlier, F., Pretolani, M., Detry, B., Heddebaut, N., Planté-Bordeneuve, T., Longchampt, E., Falque, L., Reynaud-Gaubert, M., Hirschi, S., Demant, X., Mornex, J., Tissot, A., Le Pavec, J., Messika, J., Foureau, A., Vallée, A., Pilette, C., & Brugière, O. (2022). Altered pIgR/IgA mucosal immunity in bronchiolitis obliterans syndrome. European Respiratory Journal. Supplement, 60. https://doi.org/10.1183/13993003.congress-2022.4352 (Original work published 2022)