A new degree of complexi(n)ty in the regulation of GLUT4 trafficking.
(2021) The Biochemical journal — Vol. 478, n° 7, p. 1315-1319 (2021)
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- Authors
Bultot, Laurent 
- Abstract
- Loss of the insulin-stimulated glucose uptake in muscle is a crucial event participating in the defect of whole-body metabolism in type 2 diabetes. Therefore, identification by Pavarotti et al. (Biochem. J (2021) 478 (2): 407-422) of complexin-2 as an important contributor to glucose transporter 4 (GLUT4) translocation to muscle cell plasma membrane upon insulin stimulation is essential. The present commentary discusses the biological importance of the findings and proposes future challenges and opportunities.
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Citations
Bertrand, L., De Loof, M., Beauloye, C., Horman, S., & Bultot, L. (2021). A new degree of complexi(n)ty in the regulation of GLUT4 trafficking. The Biochemical journal, 478(7), 1315-1319. https://doi.org/10.1042/BCJ20210008 (Original work published 2021)