Spinal and supraspinal pain-motor interactions and pain-related changes in brain connectivity explored by combining neuroimaging with non-invasive brain stimulation techniques
(2022)
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- Authors
- Supervisors
- Mouraux, André
- Abstract
- The aim of this project was to explore spinal and supra-spinal pain-motor interactions. First, I characterized the temporal profile and limb-specificity of the effects of a transient nociceptive stimulus on motor excitability assessed by transcranial magnetic stimulation (TMS). Secondly, I showed that the reflex elicited by intra-epidermal electrical stimulation of the sole of the foot could represent a « purer » measure of the RIII reflex than the response elicited by « conventional » transcutaneous electrical stimulation. Third, I characterized the changes in motor excitability in a state of central sensitization. In this study, high-frequency electrical stimulation of the skin does not induce sustained changes in the TMS-mapped representation of upper limb muscles. Finally, I setup the recording of functional magnetic resonance imaging (fMRI)- blood-oxygen-level-dependent (BOLD) responses elicited by TMS to explore pain-related changes in brain connectivity.
- Affiliations
Citations
Algoet, M. (2022). Spinal and supraspinal pain-motor interactions and pain-related changes in brain connectivity explored by combining neuroimaging with non-invasive brain stimulation techniques. https://hdl.handle.net/2078.5/243552