Ultra high field MRI for the characterization of murine models of cardiovascular diseases
(2018)
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- Abstract
- With the advent of transgenic and gene knockout technologies, rodents have become a cornerstone of cardiovascular research. However, accurate in vivo cardiac characterization of small animals remains challenging. In recent years, cardiac MRI has evolved to become an essential tool for experimental imaging, with progressive development of magnets operating at increasingly high field strength. In this work, we studied MRI techniques at 11.7T in mouse models of surgically induced hypertrophic and ischaemic cardiomyopathy and in an original mouse model of autoimmune cardiomyopathy. We showed that Ultra High Field MRI allows to refine characterization of such models, thanks to its great accuracy, its reproducibility and strong ability to provide specific informations on global and regional function, viability or vascular parameters. These data concur to demonstrate that this modality may provide key insights into mechanisms underlying cardiovascular diseases and indentification of new therapeutic targets.
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Citations
Vanhoutte, L. (2018). Ultra high field MRI for the characterization of murine models of cardiovascular diseases. https://hdl.handle.net/2078.5/36575