Dermatoscopic features of thin (≤2 mm Breslow thickness) vs. thick (>2 mm Breslow thickness) nodular melanoma and predictors of nodular melanoma versus nodular non-melanoma tumours: a multicentric collaborative study by the International Dermoscopy Society.

Sgouros, D; Lallas, A; Kittler, H; Zarras, A; Kyrgidis, A; Papageorgiou, C; Puig, S; Scope, A; Argenziano, G; Zalaudek, I; Pizzichetta, M A; Marghoob, A; Liopyris, K; Malvehy, J; Oikonomou, C; Flórez, A; Braun, R; Cabo, H; Nazzaro, G; Lanssens, S

doi:10.1111/jdv.16815

Dermatoscopic features of thin (≤2 mm Breslow thickness) vs. thick (>2 mm Breslow thickness) nodular melanoma and predictors of nodular melanoma versus nodular non-melanoma tumours: a multicentric collaborative study by the International Dermoscopy Society.

Sgouros, D

;

Lallas, A

;

Kittler, H

;

Zarras, A

;

Stratigos, A

;et.al.

(2020) Journal of the European Academy of Dermatology and Venereology : JEADV — Vol. 34, n° 11, p. 2541-2547 (2020)

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Authors

Sgouros, D
Author
Lallas, A
Author
Kittler, H
Author
Zarras, A
Author
Tromme, IsabelleUCLouvain
Author
Stratigos, A
Author

Abstract

BACKGROUND: Thin nodular melanoma (NM) often lacks conspicuous melanoma-specific dermatoscopic criteria and escapes clinical detection until it progresses to a thicker and more advanced tumour. OBJECTIVE: To investigate the dermatoscopic morphology of thin (≤2 mm Breslow thickness) vs. thick (>2 mm) NM and to identify dermatoscopic predictors of its differential diagnosis from other nodular tumours. METHODS: Retrospective, morphological case-control study, conducted on behalf of the International Dermoscopy Society. Dermatoscopic images of NM and other nodular tumours from 19 skin cancer centres worldwide were collected and analysed. RESULTS: Overall, 254 tumours were collected (69 NM of Breslow thickness ≤2 mm, 96 NM >2 mm and 89 non-melanoma nodular lesions). Light brown coloration (50.7%) and irregular brown dots/globules (42.0%) were most frequently observed in ≤2 mm NMs. Multivariate analysis revealed that dotted vessels (3.4-fold), white shiny streaks (2.9-fold) and irregular blue structureless area (2.4-fold) were predictors for thinner NM compared to non-melanoma nodular tumours. Overall, irregular blue structureless area (3.4-fold), dotted vessels (4.6-fold) and serpentine vessels (1.9-fold) were predictors of all NM compared to non-melanoma nodular lesions. LIMITATIONS: Absence of a centralized, consensus pathology review and cases selected form tertiary centres maybe not reflecting the broader community. CONCLUSIONS: Our study sheds light into the dermatoscopic morphology of thin NM in comparison to thicker NM and could provide useful clues for its differential diagnosis from other non-melanoma nodular tumours.

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Sgouros, D., Lallas, A., Kittler, H., Zarras, A., Kyrgidis, A., Papageorgiou, C., Puig, S., Scope, A., Argenziano, G., Zalaudek, I., Pizzichetta, M. A., Marghoob, A., Liopyris, K., Malvehy, J., Oikonomou, C., Flórez, A., Braun, R., Cabo, H., Nazzaro, G., et al. (2020). Dermatoscopic features of thin (≤2 mm Breslow thickness) vs. thick (>2 mm Breslow thickness) nodular melanoma and predictors of nodular melanoma versus nodular non-melanoma tumours: a multicentric collaborative study by the International Dermoscopy Society. Journal of the European Academy of Dermatology and Venereology : JEADV, 34(11), 2541-2547. https://doi.org/10.1111/jdv.16815 (Original work published 2020)