Mite allergen-specific IgE is detectable in bronchial secretions of patients with nonatopic asthma and correlates with mucosal expression of periostin.
(2015) Journal of Allergy and Clinical Immunology — Vol. 136, n° 6, p. 1685-1688 (2015)
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- Abstract
- (en) IgE is synthesized locally, in the bronchial mucosa, in both atopic and non-atopic asthma. The present study of bronchial secretions from asthma patients confirms that part of this IgE is specific to house dust mite (Dermatophagoïdes pteronyssinus) allergens, irrespective of atopy. In addition, it reveals that this IgE response correlates with periostin, but not to eosinophils, in sputum from these patients, probably in relation to their common IL-4/IL-13 triggering pathway.
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Mouthuy, J., Viart, S., Ladjemi, M., Detry, B., Henket, m., Bachert, C., Louis, R., & Pilette, C. (2015). Mite allergen-specific IgE is detectable in bronchial secretions of patients with nonatopic asthma and correlates with mucosal expression of periostin. Journal of Allergy and Clinical Immunology, 136(6), 1685-1688. https://doi.org/10.1016/j.jaci.2015.07.018 (Original work published 2015)