Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres.

Poirel, Hélène A;Vanspauwen, Marijke;Macq, Gilles;De Geyndt, Anke;Belgian Transplant Registry and the Belgian Haematological Society’s Transplant committee;et.al.
(2019) Bone Marrow Transplantation — Vol. 54, n° 9, p. 1434-1442 (2019)

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Authors
  • Poirel, Hélène Aorcid-logo
    Author
  • Vanspauwen, Marijke
    Author
  • Macq, Gilles
    Author
  • De Geyndt, Anke
    Author
  • Poire, XavierUCLouvain
    Author
  • Graux, CarlosUCLouvain
    Author
  • Belgian Transplant Registry and the Belgian Haematological Society’s Transplant committee
    Collaborator
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Abstract
While performance since the introduction of the JACIE quality management system has been shown to be improved for allogeneic hematopoietic stem cell transplants (HSCT), impact on autologous-HSCT remains unclear in Europe. Our study on 2697 autologous-HSCT performed in adults in 17 Belgian centres (2007-2013) aims at comparing the adjusted 1 and 3-yr survival between the different centres & investigating the impact of 3 centre-related factors on performance (time between JACIE accreditation achievement by the centre and the considered transplant, centre activity volume and type of HSCT performed by centres: exclusively autologous vs both autologous & allogeneic). We showed a relatively homogeneous performance between Belgian centres before national completeness of JACIE implementation. The 3 centre-related factors had a significant impact on the 1-yr survival, while activity volume and type of HSCT impacted the 3-yr survival of autologous-HSCT patients in univariable analyses. Only activity volume (impact on 1-yr survival only) and type of HSCT (impact on 1 and 3-yr survivals) remained significant in multivariable analysis. This is explained by the strong relationship between these 3 variables. An extended transplantation experience, i.e., performing both auto & allo-HSCT, appears to be a newly informative quality indicator potentially conveying a multitude of underlying complex factors.
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Poirel, H. A., Vanspauwen, M., Macq, G., De Geyndt, A., Maertens, J., Willems, E., Selleslag, D., Poire, X., Theunissen, K., Graux, C., Kerre, T., Zachée, P., Meuleman, N., De Becker, A., Verlinden, A., Van Obbergh, F., Schuermans, C., De Wilde, V., Jaspers, A., et al. (2019). Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres. Bone Marrow Transplantation, 54(9), 1434-1442. https://doi.org/10.1038/s41409-019-0458-8 (Original work published 2019)