Early care management after carbon monoxide poisoning based on carboxyhemoglobin toxicokinetic : on non-invasive ventilation after acute carbon monoxide exposure on swine model
(2023)
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- Abstract
- This thesis addresses the toxicokinetics of carboxyhaemoglobin (COHb) after acute carbon monoxide (CO) intoxication treated by non-invasive ventilation on a swine model. This toxicokinetic approach confirms a bi-compartmental elimination of COHb in general and suggests that calculation of the COHb half-life (COHbt1/2) could be useful for estimating the extra-vascular CO storage and the severity of CO intoxication. In addition, for the first time, we observed a rebound in COHb after treatment on normobaric oxygenation. In addition, we published the largest review of the affinity of CO for hemoglobin (M value) in the animal world, which varies according to species, and we confirm the human M value at 218. This value should become the reference in the literature on CO. In the light of these results, we propose recommendations for clinicians and for future studies on the subject.
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Citations
Delvau, N. (2023). Early care management after carbon monoxide poisoning based on carboxyhemoglobin toxicokinetic : on non-invasive ventilation after acute carbon monoxide exposure on swine model. https://hdl.handle.net/2078.5/28224