Développement d'une réaction chimique pour un nanolaboratoire
(2011)
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- Authors
- Supervisors
- Riant, Olivier
- Abstract
- (en) There is a growing interest among the scientific community to develop new technologies for adapting devices to the nanoscopic scale. This interest stems not only from the potential applications expected by going to the nanometre scale, but also from a basic interest in the new properties exhibited by materials when confined spatially. The goal of the project is thus to develop a nano-lab in which a catalytic reaction could be performed and monitored by fluorescence analyses. This nano-lab would allow us to study the behaviour of molecules (diffusion, reactivity...) when confined into a nanoscopic environment. The nano-lab consists in a nano-surface (silicon) that is designed thanks to linker (trichlorosilanes monolayer) able to be functionalized by a ligand (dipyridine moieties). The system of ligand has been synthesized and studied into the Tsuji-Trost allylic alkylation reaction and into the Tsuji-Trost alloc moieties deprotection reaction. Based on preliminary studies, BODIPY fluorophores were envisioned for monitoring the reaction by FRET (Förster Resonance Energy Transfer). Then, because of synthetic issues due to the fragility of these organic dyes, we turned to fluorogenic substrates (coumarin) to eventually established the reaction system. The grafting of the catalyst onto the trichlorosilane monolayer has been studied in order to complete the building of the nano-lab.
- Affiliations
Citations
Hensenne, P. (2011). Développement d’une réaction chimique pour un nanolaboratoire. https://hdl.handle.net/2078.5/154376