The plasma membrane H -ATPase, a simple polypeptide with a long history.
(2019) Yeast — Vol. 36, n° 4, p. 201-210 (2019)
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- Authors
Palmgren, Michael 
- Abstract
- The plasma membrane H -ATPase of fungi and plants is a single polypeptide of fewer than 1,000 residues that extrudes protons from the cell against a large electric and concentration gradient. The minimalist structure of this nanomachine is in stark contrast to that of the large multi-subunit F F ATPase of mitochondria, which is also a proton pump, but under physiological conditions runs in the reverse direction to act as an ATP synthase. The plasma membrane H -ATPase is a P-type ATPase, defined by having an obligatory phosphorylated reaction cycle intermediate, like cation pumps of animal membranes, and thus, this pump has a completely different mechanism to that of F F ATPases, which operates by rotary catalysis. The work that led to these insights in plasma membrane H -ATPases of fungi and plants has a long history, which is briefly summarized in this review.
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Citations
Palmgren, M., & Morsomme, P. (2019). The plasma membrane H -ATPase, a simple polypeptide with a long history. Yeast, 36(4), 201-210. https://doi.org/10.1002/yea.3365 (Original work published 2019)