Changes in Pro-Inflammatory Markers in Detoxifying Chronic Alcohol Abusers, Divided by Lesch Typology, Reflect Cognitive Dysfunction
(2017) Alcohol and Alcoholism — Vol. 52, n° 5, p. 521-528 (2017)
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- (en) Aim: To investigate pro-inflammatory markers in the blood and associate with cognitive impairment. Methods:: Il-6 and ferritin were assayed in the blood of 27 patients, divided according to Lesch typology, at the commencement and after 21 days of detoxification, together with a battery of cog- nitive tests. Results: A significantly higher mean level of IL-6 was present in the blood of patients with Lesch typology 1 compared to the other typologies 2 and 3 on admission to the Detoxification Ward which did not alter significantly after detoxification. The mean level of IL-6 was initially elevated in Lesch typology 2 alcohol abusers and declined to the reference range after detoxification. Lesch typology 3 alcohol abusers showed normal levels of IL-6 at both time points. Only in Lesch typ- ology 1 were the levels of ferritin and IL-10 significantly elevated at the start of the detoxification process. Cognitive impairment, as ascertained by Stroop test and Brown–Peterson procedure was greater in Lesch typology 1 than the other 2 patient groups. Conclusion: Such data might indicate a greater degree of neuroinflammation in Lesch typology 1 alcoholic patients.
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Hanak, C., Benoit, J., Fabry, L., Hein, M., Verbanck, P., De Witte, P., Walter, H., Dexter, D. T., & Ward, R. J. (2017). Changes in Pro-Inflammatory Markers in Detoxifying Chronic Alcohol Abusers, Divided by Lesch Typology, Reflect Cognitive Dysfunction. Alcohol and Alcoholism, 52(5), 521-528. https://doi.org/10.1093/alcalc/agx043 (Original work published 2017)