This work aims at renewing the knowledge on the transition from alcohol-dependence to Korsakoff syndrome by testing the continuity hypothesis in the framework of the dual-process models. The three following experimental objectives were addressed by assessing respectively: (1) The frontal-reflective system (determining the differential deficits across the subcomponents of executive processes); (2) The limbic automatic-affective system (associated with emotional processes but also with impulsive/appetitive processes triggered by alcohol-related stimuli); (3) The dysfunctional interaction between these two systems (exploring the interactions between cognition and emotion). This research offers the originality of a combined behavioral-neuroscience approach (i.e. electrophysiological investigation of neural correlates underlying cognitive processes) and progressive approach (determining the dysfunctional interaction of the two systems by comparing abilities across the successive stages of the pathology).
Brion, M. (2017). A dual-process model exploration of executive and emotional dysfunctions in alcohol-dependence and Korsakoff syndrome. https://hdl.handle.net/2078.5/71782