Planar cell polarity genes control the connectivity of enteric neurons
(2013) Journal of Clinical Investigation — Vol. 123, n° 4, p. 1763-1772 (2013)
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- Authors
Tissir, Fadel 
- Abstract
- molecular mechanisms that regulate their assembly into functional neuronal circuits are currently unknown. Here we report that the planar cell polarity (PCP) genes Celsr3 and Fzd3 are required during murine embryogenesis to specifically control the guidance and growth of enteric neuronal projections relative to the longitudinal and radial gut axes. Ablation of these genes disrupts the normal organization of nascent neuronal projections, leading to subtle changes of axonal tract configuration in the mature enteric nervous system (ENS), but profound abnormalities in gastrointestinal motility. Our data argue that PCP-dependent modules of connectivity established at early stages of enteric neurogenesis control gastrointestinal function in adult animals and provide the first evidence that developmental deficits in ENS wiring may contribute to the pathogenesis of idiopathic bowel disorders.
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Citations
Sasselli, V., Boesmans, W., Vanden Berghe, P., Tissir, F., Goffinet, A., & Pachnis, V. (2013). Planar cell polarity genes control the connectivity of enteric neurons. Journal of Clinical Investigation, 123(4), 1763-1772. https://doi.org/10.1172/JCI66759 (Original work published 2013)