Temocillin plasma and pancreatic tissue concentrations in a critically ill patient with septic shock.
(2019) Journal of Antimicrobial Chemotherapy — Vol. 74, n° 5, p. 1459-1461 (2019)
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- Authors
Tulkens, Paul M. 
- Abstract
- Sir, Resistance of Gram-negative pathogens to current antibiotics has revived interest in earlier and often disused molecules for which resistance is still low. Yet, detailed pharmacokinetic/pharmacodynamic data are scarce for these drugs. A typical example is temocillin (6-α-methoxy-ticarcillin), active against most Gram-negative bacteria, which shows stability against a variety of β-lactamases, including most ESBLs, AmpC and some carbapenemases. Temocillin represents a strategic sparing alternative to carbapenems.1 There is no EUCAST breakpoint set for temocillin, but in recent surveys, MIC90 values of 8–16 mg/L were reported for ESBL and AmpC producers [...]
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Citations
Ngougni Pokem, P., Capron, A., Wallemacq, P., Tulkens, P. M., Van Bambeke, F., & Laterre, P.-F. (2019). Temocillin plasma and pancreatic tissue concentrations in a critically ill patient with septic shock. Journal of Antimicrobial Chemotherapy, 74(5), 1459-1461. https://doi.org/10.1093/jac/dky565 (Original work published 2019)