Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development.
(2010) Neuroscience — Vol. 165, n° 1, p. 116-129 (2010)
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- Abstract
- The Onecut transcription factors, namely HNF-6, OC-2 and OC-3, are transcriptional activators expressed in liver, pancreas and nervous system during development. Although their expression and roles in endoderm-derived tissues and in the trigeminal ganglia have been investigated, their expression in the CNS has not been described yet. In this study, we report a qualitative and quantitative expression profile of the Onecut factors in the developing spinal motor neurons. We provide evidence that Onecut expression is initiated in newly-born motor neurons. At later stages, they are differentially and dynamically expressed in subsets of differentiating motor neuron within the four motor columns. We also show that the expression profile of HNF-6 in spinal motor neurons is conserved in chick embryos. Together, our data unveil a complex and dynamic expression profile of the Onecut proteins in spinal motor neurons, which suggests that these factors may participate in regulatory networks that control different steps of motor neuron development.
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Francius, C., & Clotman, F. (2010). Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development. Neuroscience, 165(1), 116-129. https://doi.org/10.1016/j.neuroscience.2009.09.076 (Original work published 2010)