Modulation of the gut microbiota is one of the promising tools to tackle obesity. Chang and colleagues have recently shown that an extract of the mushroom Ganoderma lucidum, a traditional remedy in Asia, can reduce obesity in mice by modulating the gut microbiota, thereby exerting a prebiotic effect.
Delzenne, N., & Bindels, L. (2015). Gut microbiota: Ganoderma lucidum, a new prebiotic agent to treat obesity? Nature Reviews Gastroenterology & Hepatology, 12(10), 553-554. https://doi.org/10.1038/nrgastro.2015.137 (Original work published 2015)