The Potential Role of the Dipeptidyl Peptidase-4-Like Activity From the Gut Microbiota on the Host Health
(2018) Frontiers in Microbiology — Vol. 9, p. 1900 [1-10] (2018)
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- Abstract
- The Dipeptidyl peptidase-4 (DPP-4) activity influences metabolic, behavioral and intestinal disorders through the cleavage of key hormones and peptides. Some studies describe the existence of human DPP-4 homologs in commensal bacteria, for instance in Prevotella or Lactobacillus. However, the role of the gut microbiota as a source of DPP-4-like activity has never been investigated. Through the comparison of the DPP-4 activity in the cecal content of germ-free mice (GFM) and gnotobiotic mice colonized with the gut microbiota of a healthy subject, we bring the proof of concept that a significant DPP-4-like activity occurs in the microbiota. By analyzing the existing literature, we propose that DPP-4-like activity encoded by the intestinal microbiome could constitute a novel mechanism to modulate protein digestion as well as host metabolism and behavior.
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Olivares Sevilla, M., Schüppel, V., Hassan, A. M., Beaumont, M., Neyrinck, A., Bindels, L., Benítez-Páez, A., Sanz, Y., Haller, D., Holzer, P., & Delzenne, N. (2018). The Potential Role of the Dipeptidyl Peptidase-4-Like Activity From the Gut Microbiota on the Host Health. Frontiers in Microbiology, 9, 1900 [1-10]. https://doi.org/10.3389/fmicb.2018.01900 (Original work published 2018)