Adverse effects of low occuptional cadmium exposure on renal and oxidative stress biomarkers in solderers.

Hambach, Ramona;Lison, Dominique;D'Haese, Patrick;Weyler, Joost;van Sprundel,Marc;et.al.
(2013) Occupational and Environmental Medicine : an international peer-reviewed journal in all aspects of occupational & environmental medicine — Vol. 70, n° 2, p. 108-113 (2013)

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Authors
  • Hambach, RamonaUA
    Author
  • Lison, Dominiqueorcid-logoUCLouvain
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  • D'Haese, Patrick
    Author
  • Weyler, Joost
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  • van Sprundel,Marc
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Abstract
Objectives Recent studies suggest adverse health effects after low exposure to cadmium (Cd). Brazing with Cd-containing solder exposes workers to Cd. The purpose of this study was to assess: (1) indicators of Cd exposure in blood (Cd-B)/ urine (Cd-U); (2) the association between Cd-B, Cd-U and renal and oxidative stress biomarkers. Methods In this cross-sectional study Cd-B, Cd-U, renal (ie, N-acetyl-β-D-glucosaminidase/urinary intestinal alkaline phosphatase (IAP)/microalbumin/beta-2-microglobulin/retinol binding protein and oxidative stress markers (ie, derivatives of reactive oxygen metabolites/glutathione peroxidase/superoxide dismutase (SOD)/ advanced oxidation protein products/8-hydroxy-2′-deoxyguanosin/8-isoprostanes) were determined in 36 solderers. Results Multiple linear regression analysis adjusting for age and pack-years of smoking show that IAP is statistically significantly associated with Cd-B (B=0.24; SE=0.11) and Cd-U (B=0.15; SE=0.07). Also SOD is statistically significantly associated with Cd-B (B=62.96; SE=29.62). The association between SOD and Cd-U is of borderline statistical significance (B=37.69; SE=19.59). Conclusions While there is still some debate as whether the Cd-induced tubular effects are reversible or not, IAP and SOD appear as sensitive and potentially useful early biomarkers for the health surveillance of workers exposed to low levels of Cd.
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Hambach, R., Lison, D., D’Haese, P., Weyler, J., François, G., De Schryver, A., Manuel-Y-Keenoy, B., Van Soom, U., Caeyers, T., & van Sprundel, M. (2013). Adverse effects of low occuptional cadmium exposure on renal and oxidative stress biomarkers in solderers. Occupational and Environmental Medicine : an international peer-reviewed journal in all aspects of occupational & environmental medicine, 70(2), 108-113. https://doi.org/10.1136/oemed-2012-100887 (Original work published 2013)