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Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes

El Mahdaoui, Amal;Radi, Smaail;Draoui, Youssef;El Massaoudi, Mohamed;Garcia, Yann;et.al.
(2024) Molecules : a journal of synthetic organic and natural product chemistry — Vol. 29, n° 5, p. 1186 (2024)

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Authors
  • El Mahdaoui, Amalorcid-logo
    Author
  • Radi, Smaailorcid-logo
    Author
  • Draoui, Yousseforcid-logo
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  • El Massaoudi, Mohamed
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  • Robeyns, Koenorcid-logoUCLouvain
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  • Garcia, Yannorcid-logoUCLouvain
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Abstract
In this study, we synthesized two coordination complexes based on pyrazole-based ligands, namely 1,5-dimethyl-N-phenyl-1H-pyrazole-3-carboxamide (L1) and 1,5-dimethyl-N-propyl-1H-pyrazole-3-carboxamide (L2), with the aim to investigate bio-inorganic properties. Their crystal structures revealed a mononuclear complex [Ni(L1)2](ClO4)2 (C1) and a dinuclear complex [Cd2(L2)2]Cl4 (C2). Very competitive antifungal and anti-Fusarium activities were found compared to the reference standard cycloheximide. Additionally, L1 and L2 present very weak genotoxicity in contrast to the observed increase in genotoxicity for the coordination complexes C1 and C2.
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El Mahdaoui, A., Radi, S., Draoui, Y., El Massaoudi, M., Ouahhoud, S., Asehraou, A., Bentouhami, N. E., Saalaoui, E., Benabbes, R., Robeyns, K., & Garcia, Y. (2024). Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes. Molecules : a journal of synthetic organic and natural product chemistry, 29(5), 1186. https://doi.org/10.3390/molecules29051186 (Original work published 2024)