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Assessment of presumed small-molecule ligands of telomeric i-DNA by biolayer interferometry (BLI)

Bonnet, Hugues;Morel, Maéva;Devaux, Alexandre;Boissieras, Joseph;Defrancq, Eric;et.al.
(2022) Chemical Communications — Vol. 58, n° 33, p. 5116-5119 (2022)

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Authors
  • Bonnet, Hugues
    Author
  • Morel, Maéva
    Author
  • Devaux, Alexandre
    Author
  • Boissieras, Joseph
    Author
  • Elias, Benjaminorcid-logoUCLouvain
    Author
  • Dejeu, Jérômeorcid-logoUCLouvain
    Author
  • Defrancq, Ericorcid-logoUCLouvain
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Abstract
Biolayer interferometry (BLI) and circular dichroism (CD) spectroscopy were used to investigate the interaction between previously reported i-motif DNA (i-DNA) ligands and folded or unfolded i-DNA in acidic (pH 5.5) and near-neutral (pH 6.5) conditions. We observed that although several ligands, in particular macrocyclic bis-acridine (BisA) and pyridostatin (PDS), showed good affinities for the telomeric i-motif forming sequence, none of the ligands displayed selective interactions with the i-DNA structure nor was able to promote its formation.
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Bonnet, H., Morel, M., Devaux, A., Boissieras, J., Granzhan, A., Elias, B., Lavergne, T., Dejeu, J., & Defrancq, E. (2022). Assessment of presumed small-molecule ligands of telomeric i-DNA by biolayer interferometry (BLI). Chemical Communications, 58(33), 5116-5119. https://doi.org/10.1039/d2cc00836j (Original work published 2022)