One-sequence mechanochemical synthesis-deracemisation of a levetiracetam intermediate

Wery, Guillaume; Leyssens, Tom

doi:10.1039/d6mr00053c

One-sequence mechanochemical synthesis-deracemisation of a levetiracetam intermediate

Wery, Guillaume

;

Leyssens, Tom

(2026) RSC Mechanochemistry — (2026)

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Authors

Wery, GuillaumeUCLouvain
Author
Leyssens, TomUCLouvain
Author

Abstract

Starting from a racemic building block, we introduce a one-pot mechanochemical synthesis of enantioenriched 2-(benzylideneamino)butanamide, a key intermediate for the enantiopure drug levetiracetam. Optimisation leads to an ee of up to 94% ee with an overall 80% isolated yield.

Affiliations

UCLouvainSST/IMCN/MOST - Molecular Chemistry, Materials and Catalysis

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Wery, G., & Leyssens, T. (2026). One-sequence mechanochemical synthesis-deracemisation of a levetiracetam intermediate. RSC Mechanochemistry. Published. https://doi.org/10.1039/d6mr00053c (Original work published 2026)