Shaking things up: exploiting the potential of mechanochemistry to enhance deracemization of racemic compounds

Pinètre, Clément;Lopes, Chrystal;Coquerel, Gérard;Leyssens, Tom;Brandel, Clément;et.al.
(2026) Chemical Communications — Vol. 62, n° 49, p. 12407-12410 (2026)

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Authors
  • Pinètre, Clémentorcid-logoUniv Rouen Normandie, Normandie Univ, SMS, UR 3233, Rouen F-76000, France
    Author
  • Lopes, ChrystalUniv Rouen Normandie, Normandie Univ, SMS, UR 3233, Rouen F-76000, France
    Author
  • Coquerel, Gérardorcid-logoUniv Rouen Normandie, Normandie Univ, SMS, UR 3233, Rouen F-76000, France
    Author
  • Leyssens, TomUCLouvain
    Author
  • Brandel, Clémentorcid-logoUniv Rouen Normandie, Normandie Univ, SMS, UR 3233, Rouen F-76000, France
    Author
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Abstract
A chiral substance crystallizing as a racemic compound was deracemized using mechanochemistry. The material was engineered as a mixed crystal with a compound crystallizing as a conglomerate. A threefold increase in the yield of deracemization using high-energy milling was observed compared to the conventional solution process due to improved solid-state miscibility.
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Pinètre, C., Lopes, C., Coquerel, G., Leyssens, T., Cartigny, Y., Dupray, V., & Brandel, C. (2026). Shaking things up: exploiting the potential of mechanochemistry to enhance deracemization of racemic compounds. Chemical Communications, 62(49), 12407-12410. https://doi.org/10.1039/d6cc01337f (Original work published 2026)