Pathophysiological response in trauma-related acute kidney injury after blunt thoracic trauma and hemorrhagic shock in male mice
(2025) American Journal of Physiology: Renal Physiology — Vol. 329, n° 2, p. F311-F322 (2025)
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- Authors
Halbgebauer, Rebecca 
Borgel, Onno Huber-Lang, Markus S.
- Abstract
- <jats:p>This study introduces a murine model of trauma-related acute kidney injury (TRAKI) via combined blunt thoracic trauma and hemorrhage, revealing transient kidney dysfunction despite normal morphology. Early damage to proximal tubular cells, inflammatory responses, and induction of stress markers like heme oxygenase-1 were observed. Proteomic analyses uncovered distinct intrarenal changes, whereas three-dimensional microcomputed tomography showed capillary blood supply impairment, resolving by day 5. These findings shed light on TRAKI’s pathophysiology and may inform future therapeutic strategies.</jats:p>
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Citations
Halbgebauer, R., Schult, L., Borgel, O., Maes, A., Weißhaupt, F., Rastner, C., Ast, A., Lupu, L., Palmer, A., Wachter, U., Schmidt, S. A., Boor, P., Rösler, R., Wiese, S., Kerckhofs, G., & Huber-Lang, M. S. (2025). Pathophysiological response in trauma-related acute kidney injury after blunt thoracic trauma and hemorrhagic shock in male mice. American Journal of Physiology: Renal Physiology, 329(2), F311-F322. https://doi.org/10.1152/ajprenal.00029.2025 (Original work published 2025)