Mammary carcinoma in aged gerbil mothers after endocrine disruption in pregnancy and lactation

Ruiz, Thalles;Colleta, Simone;Rivas Leonel, Ellen;Taboga, Sebastião
(2021) Endocrine-Related Cancer — Vol. 28, n° 11, p. 715-730 (2021)

Files

Ruiz et al., 2021 - Endocrine-Related Cancer.pdf
  • Open Access
  • Adobe PDF
  • 3.97 MB
Download

Details

Authors
  • Ruiz, Thalles1Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), Jardim Nazareth, São José do Rio Preto, São Paulo, Brazil
    Author
  • Colleta, Simone1Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), Jardim Nazareth, São José do Rio Preto, São Paulo, Brazil
    Author
  • Rivas Leonel, EllenUCLouvain
    Author
  • Taboga, Sebastião1Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), Jardim Nazareth, São José do Rio Preto, São Paulo, Brazil
    Author
Abstract
Compounds that trigger breast cancer onset and establishment are of great interest in biological research. Endocrine disruptors are relevant because they initiate carcinogenesis by changing endocrine pathways. Bisphenol A (BPA), as a ubiquitous xenoestrogen, is largely associated with dysfunctions in the female reproductive system and associated organs. This study proposes an investigation of the mammary gland (MG) in aged Mongolian gerbil (Meriones unguiculatus) mothers after their exposure to BPA in two windows of morphophysiological plasticity: pregnancy and lactation. A low dose (50 μg/kg) and a high dose (5000 μg/kg) of BPA were considered, and results showed few differences between them. As expected, we observed contrasts among control and BPA-exposed MG. The control groups presented a regressive phase with high apoptotic activity and elastic stroma. However, BPA damaged mammary tissue and provoked multifocal carcinoma development supported by an apparent epithelial-mesenchymal transition (EMT) and reactive stroma establishment. BPA remodeled stromal fibers deposition and enhanced the recruitment of tumor-associated cells, contributing to a tumoral microenvironment. Overexpression of TGF-β1 was induced by BPA in the epithelial compartment of exposed MG, and increased expression of metalloproteinases (MMP-2, MMP-3, MMP-9) was present in carcinoma cells. In conclusion, exposure of mothers to BPA during the gestational/lactational window of susceptibility leads to carcinogenic impacts with aging.
Affiliations

Citations

  • APA
  • Chicago
  • FWB

Ruiz, T., Colleta, S., Rivas Leonel, E., & Taboga, S. (2021). Mammary carcinoma in aged gerbil mothers after endocrine disruption in pregnancy and lactation. Endocrine-Related Cancer, 28(11), 715-730. https://doi.org/10.1530/erc-21-0198 (Original work published 2021)