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Abstract
The locus coeruleus-norepinephrine (LC-NE) system has been implicated in perceptual decision-making, but its causal contribution and underlying mechanisms in humans remain unclear. Here, we used transcutaneous vagus nerve stimulation (tVNS) to modulate LC-NE activity during a random dot motion task, with stimulation delivered at three distinct time points across groups, each targeting different stages of LC-NE engagement during the task. tVNS reliably increased pupil-linked LC-NE activity across all groups. Notably, early stimulation, at a time when LC-NE activity was still at baseline, elicited a more sustained pupil dilation that extended into the decision phase, resulting in comparable pupil responses during decision-making across groups. For behavior, tVNS selectively improved decision accuracy in contexts characterized by initially low performance, without affecting response times. Drift diffusion modeling revealed that this improvement was specifically associated with increased drift rate, consistent with more efficient evidence accumulation with tVNS. These effects were consistent across groups but most pronounced when tVNS was applied at the early time point. Our results provide causal evidence that tVNS enhances decision-making in a state-dependent manner, likely by stabilizing attentional engagement and facilitating evidence accumulation when endogenous control is suboptimal.
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Su, S., Vanvoorden, T., Denmat, P., Zenon, A., & Duque, J. (2025). Transcutaneous Vagus Nerve Stimulation boosts evidence accumulation during perceptual decision-making. iScience. Accepted/in-press. https://doi.org/10.1101/2025.06.27.662007 (Original work published 2026)