The recent results of the study evaluating the impact of macrophage transplantation in cirrhosis with the aim of improving liver function open up a number of prospects. Although negative, fewer deaths were observed, as well as a favourable cytokine profile. This is in line with other results obtained in liver disease, notably through signalling and regeneration studies on human liver tissue. For the future, a number of questions need to be answered if we are to make progress in this fascinating field.
Lanthier, N., & Spahr, L. (2025). Macrophage therapy and liver regeneration: Results and perspectives. Clinics and Research in Hepatology and Gastroenterology, 49(4), 102569. https://doi.org/10.1016/j.clinre.2025.102569 (Original work published 2025)