Towards the clinical use of peripheral bile acids: Recommendations to limit their preanalytical and analytical sources of variability
(2025) Practical Laboratory Medicine — Vol. 1, n° 1, p. e00508 (2025)
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- Abstract
- Inconsistent peripheral bile acid data hinders their use as liver injury biomarkers. We analyzed 65 studies and 215 patient cohorts to uncover variability determinants. We identified preanalytical and analytical factors causing variability. We propose specific standardized procedural recommendations for bile acid analysis. The recommendations aim to enhance the comparability of future bile acid studies.
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Citations
Joseph, S., de Buyl, S., Leclercq, I., Serafimov, K., Feron, O., & Clerbaux, L.-A. (2025). Towards the clinical use of peripheral bile acids: Recommendations to limit their preanalytical and analytical sources of variability. Practical Laboratory Medicine, 1(1), e00508. https://doi.org/10.1016/j.plabm.2025.e00508 (Original work published 2025)