A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment
(2024) Bioactive materials — Vol. 32, p. 206-221 (2024)
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- Current treatments for inflammatory bowel disease (IBD) treatment consist of anti-inflammatory products. In this study, we sought to induce the physiological secretion of glucagon-like peptide 2, a peptide with intestinal growth-promoting activity, via nanoparticles while simultaneously providing with immunomodulation by tailoring the nanoparticle surface. To this end, we developed hybrid lipid hyaluronate-KPV conjugated nanoparticles loaded with teduglutide for combination therapy in IBD. The nanocarriers induced (or did not induce) immunosuppression depending on the presence (or absence) of a hyaluronan-KPV functionalization. This strategy holds promise as a nanoparticle platform for combined mucosal healing and immunomodulation in IBD treatment.
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Marotti, V., Xu, Y., Bohns Michalowski, C., Zhang, W., Ladeiro Domingues, I., Ameraoui, H., Moreels, T., Baatsen, P., Van Hul, M., Muccioli, G., Cani, P., Al Houayek, M., Malfanti, A., & Beloqui Garcia, A. (2024). A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment. Bioactive materials, 32, 206-221. https://doi.org/10.1016/j.bioactmat.2023.09.014 (Original work published 2024)