Which traits affect how long patients with advanced prostate cancer live when treated with enzalutamide?
(2022) Future Oncology — Vol. 18, n° 35, p. 3867-3874 (2022)
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- Abstract
- This is a summary of a research article originally published in . The PROSPER study involved men who had a type of advanced prostate cancer called nonmetastatic castration-resistant prostate cancer (nmCRPC). In men with nmCRPC, their cancer has progressed on traditional hormone therapy but scans show that it has not spread to other parts of the body. The main results of the PROSPER study showed that patients treated with enzalutamide lived longer than patients treated with placebo. For this analysis, researchers looked at whether this was different depending on patients' traits. Researchers found that age and location did not affect how long patients lived when treated with enzalutamide. They found three patient traits that did make a difference. Being able to carry out daily activities, low prostate-specific antigen level (PSA level), and receiving no other prostate cancer treatments after the study meant that patients were more likely to live longer. Patients with nmCRPC treated with enzalutamide lived longer than patients treated with placebo. Age and location did not affect how long these patients lived, but other traits did. : NCT02003924 (ClinicalTrials.gov).
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Citations
De Giorgi, U., Hussain, M., Shore, N., Fizazi, K., Tombal, B., Penson, D., Saad, F., Efstathiou, E., Madziarska, K., Steinberg, J., Sugg, J., Lin, X., Shen, Q., & Sternberg, C. N. (2022). Which traits affect how long patients with advanced prostate cancer live when treated with enzalutamide? Future Oncology, 18(35), 3867-3874. https://doi.org/10.2217/fon-2022-0661 (Original work published 2022)