Coordination Complexes and Polymers of Novel Hybrid Tetrazole-Triazole–Pyrazole Ligands: Synthesis, Structural Characterization, and Biological Evaluation
(2026) Chemistry: A European Journal — (2026)
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- Abstract
- New series of triazole/pyrazole and tetrazole/triazole/pyrazole ligands were synthesized and coordinated with various transition metals to yield a diverse library of 14 complexes. All compounds were fully characterized by elemental analysis, mass spectrometry, powder X-ray diffractometry, and a range of spectroscopic techniques (1 H NMR,13 C NMR, FT-IR, and UV–visible diffuse reflectance). The crystal and molecular structures were elucidated via single-crystal X-ray diffraction, and their supramolecular features were explored through Hirshfeld surface analysis. The 57 Fe Mössbauer and magnetic SQUID measurements confirmed the high-spin nature of the FeII complex 1 . In the three human cancer cell lines, most metal complexes are somewhat more cytotoxic than the inactive ligands, with Co(II) complexes 2 and 8 being the most potent in two of the cell lines (with IC50 values in the two-digit micromolar range). Overall, this study highlights how blending tetrazole/triazole/pyrazole ligands with transition metals can lead to coordination compounds with potential in anticancer research, as a proof of concept. These results add valuable insight to the expanding field of metal-based therapeutics and could help guide the development of next-generation, more effective agents.
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Bahjou, Y., Draoui, Y., Radi, S., Robeyns, K., Li, W., Rotaru, A., Garcia, Y., & et al. (2026). Coordination Complexes and Polymers of Novel Hybrid Tetrazole-Triazole–Pyrazole Ligands: Synthesis, Structural Characterization, and Biological Evaluation. Chemistry: A European Journal. Accepted/in-press. https://doi.org/10.1002/chem.202502238 (Original work published 2026)