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Transaminase membrane-immobilization for intensified chiral amines production

Meersseman Arango, Hippolyte;Leyssens, Tom;Luis Alconero, Patricia;Paradisi, Francesca;Debecker, Damien
(2023) PREPA13 - 13th International Symposium on “Scientific Bases for the Preparation of Heterogeneous Catalysts” — Location: Louvain-la-Neuve, Belgium (2023.July.9AD)

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Abstract
Coupling transaminases with membrane technology in an enzyme membrane reactor is of particular interest, as it could allow the selective removal of products during operation. Enzymes onto polymeric membranes has already been reported, e.g. with lipase or glucose oxidase but not transaminase4. As proof of concept, we present the immobilization of an ATA from Halomonas elongata (HeWT) onto polypropylene (PP) and polyacrylonitrile-based (PAN) membranes and its application to catalyze a model transamination.
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Meersseman Arango, H., Leyssens, T., Luis Alconero, P., Paradisi, F., & Debecker, D. (2023). Transaminase membrane-immobilization for intensified chiral amines production. PREPA13 - 13th International Symposium on “Scientific Bases for the Preparation of Heterogeneous Catalysts”, Louvain-la-Neuve, Belgium. https://hdl.handle.net/2078.5/26604