Severe hypercalcaemia early after kidney transplantation in two patients with severe secondary hyperparathyroidism previously treated with etelcalcetide.
(2021) Clinical Kidney Journal — Vol. 14, n° 8, p. 1977-1979 (2021)
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- Abstract
- Cinacalcet and, more recently, etelcalcetide revolutionized the treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney transplant (KT) usually improves CKD-MBD. However, a significant proportion of KT recipients have high serum calcium levels, not requiring any treatment. We report two patients previously treated with etelcalcetide who developed severe (>3.3 mmol/L) hypercalcaemia in the early post-KT course, requiring parathyroidectomy. Pathological studies showed parathyroid adenomas and hyperplasia. One patient had a graft biopsy showing numerous intratubular calcium phosphate crystals. These observations should prompt pharmacovigilance studies and careful follow-up of KT recipients previously treated with etelcalcetide.
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Dachy, G., Pochet, J.-M., Labriola, L., Buemi, A., Gillion, V., Jadoul, M., Kanaan, N., & Devresse, A. (2021). Severe hypercalcaemia early after kidney transplantation in two patients with severe secondary hyperparathyroidism previously treated with etelcalcetide. Clinical Kidney Journal, 14(8), 1977-1979. https://doi.org/10.1093/ckj/sfab063 (Original work published 2021)