New triazole-based coordination complexes as antitumor agents against triple negative breast cancer MDA-MB-468 cell line
(2023) RSC Advances — Vol. 13, n° 51, p. 36158-36167 (2023)
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- Authors
Draoui, Youssef 
Radi, Smaail Idir, Abderrazak
- Abstract
- The present work describes the synthesis of a new triazole based ligand 3-(3,5-dimethyl-1H-pyrazol-1-yl)-1-methyl-1H-1,2,4-triazole (LM) and demonstration of its coordination diversity giving rise to a family of seven new coordination complexes, namely: [Ni(LM)3](ClO4)2·C2H6OS (5), [Co2(LM)6](ClO4)4·(C2H5)O (6), [Cd(LM)2Cl2] (7), [Cu(LM)2NO3]NO3 (8), [Fe(LM)3](BF4)2 (9), [Zn(LM)3](BF4)2 (10) and [Zn(LM)2NO3]NO3 (11), whose crystal structure was determined by single-crystal X-ray diffraction. Cytotoxic activity was evaluated against the MDA-MB-468 cancer cell line, which serves as a model for triple-negative breast cancer, and compared to the precursor molecule (L), as well as their coordination complexes (H3O){[NiL3](ClO4)3} (1), [CoL3](ClO4)2·2H2O (2), [CdL2Cl2] (3) and [CuL3](NO3)2 (4), for which the crystal structure was earlier determined. Notably, cadmium complexes 3 and 7 exhibit remarkable cytotoxicity and demonstrated a high selectivity index towards cancer cells when compared to peripheral blood mononuclear cells. Such activity highlights their potential function as anticancer agents.
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Citations
Draoui, Y., Radi, S., Bahjou, Y., Idir, A., El Mahdaoui, A., Zyad, A., Miras, H. N., Ferbinteanu, M., Rotaru, A., & Garcia, Y. (2023). New triazole-based coordination complexes as antitumor agents against triple negative breast cancer MDA-MB-468 cell line. RSC Advances, 13(51), 36158-36167. https://doi.org/10.1039/d3ra07714d (Original work published 2023)