Cu(II) Pyrazolyl-benzimidazole Dinuclear Complexes with Remarkable Antioxidant Activity
(2023) ChemBioChem : a European journal of chemical biology — Vol. 24, n° 20, p. e202300331 (2023)
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- Authors
Chkirate, Karim 
Karrouchi, Khalid Fettach, Saad Radi, Smaail
- Abstract
- Three dinuclear coordination complexes generated from 1-n-butyl-2-((5-methyl-1H-pyrazole-3-yl)methyl)-1H-benzimidazole (L), have been synthesized and characterized spectroscopically and structurally by single crystal X-ray diffraction analysis. Reaction with iron(II) chloride and then copper(II) nitrate led to a co-crystal containing 78 % of [Cu(NO3)(μ-Cl)(L’)]2 (C1) and 22 % of [Cu(NO3)(μ-NO3)(L’)]2 (C2), where L was oxidized to a new ligand L’. A mechanism is provided. Reaction with copper chloride led to the dinuclear complex [Cu(Cl)(μ-Cl)(L)]2 (C3). The presence of N−H⋅⋅⋅O and C−H⋅⋅⋅O intermolecular interactions in the crystal structure of C1 and C2, and C−H⋅⋅⋅N and C−H⋅⋅⋅Cl hydrogen bonding in the crystal structure of C3 led to supramolecular structures that were confirmed by Hirshfeld surface analysis. The ligands and their complexes were tested for free radical scavenging activity and ferric reducing antioxidant power. The complex C1/C2 shows remarkable antioxidant activities as compared to the ligand L and reference compounds.
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Chkirate, K., Ati, G. A., Karrouchi, K., Fettach, S., Chakchak, H., Mague, J. T., Radi, S., Adarsh, N. N., Abbes Faouzi, M. E., Essassi, E. M., & Garcia, Y. (2023). Cu(II) Pyrazolyl-benzimidazole Dinuclear Complexes with Remarkable Antioxidant Activity. ChemBioChem : a European journal of chemical biology, 24(20), e202300331. https://doi.org/10.1002/cbic.202300331 (Original work published 2023)