ROR2 regulates self-renewal and maintenance of hair follicle stem cells
(2022) Nature Communications — Vol. 13, n° 1, p. 4449 [1-17] (2022)
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- (en) Hair follicles undergo cycles of regeneration fueled by hair follicle stem cells (HFSCs). While β-catenin-dependent canonical Wnt signaling has been extensively studied and implicated in HFSC activation and fate determination, very little is known about the function of β-catenin-independent Wnt signaling in HFSCs. In this study, we investigate the functional role of ROR2, a Wnt receptor, in HFSCs. By analyzing Ror2-depleted HFSCs, we uncover that ROR2 is not only essential to regulate Wnt-activated signaling that is responsible for HFSC activation and self-renewal, but it is also required to maintain proper ATM/ATR-dependent DNA damage response which is indispensable for the long-term maintenance of HFSCs. In analyzing HFSCs lacking β-catenin, we identify a compensatory role of ROR2-PKC signaling in protecting β-catenin-null HFSCs from the loss of stem cell pool. Collectively, our study unveils a previously unrecognized role of ROR2 in regulation of stem cell self-renewal and maintenance.
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Veltri, A., Lang, C. M. R., Cangiotti, G., Chan, C. K., & Lien, W.-H. (2022). ROR2 regulates self-renewal and maintenance of hair follicle stem cells. Nature Communications, 13(1), 4449 [1-17]. https://doi.org/10.1038/s41467-022-32239-7 (Original work published 2022)