Fertility preservation in Turner girls: to do or not to do?
(2023) Fertility and sterility — Vol. 120, n° 5, p. 993-994 (2023)
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Donnez, Jacques 
- Abstract
- (en) In their study, Nadesapillai et al. set out to answer a critical question, namely, “Based on karyotype, puberty status, and hormonal data, which girls with Turner syndrome (TS) could benefit from fertility preservation by ovarian tissue cryopreservation (OTC)?” The question is crucial because signs of a depleted ovarian reserve are often encountered at an early age, so OTC could be a way of preserving the follicle pool of these girls before premature ovarian insufficiency (POI) occurs. Indeed, only a third of girls with TS enter puberty, although the majority experience POI at a young age because of extensive and accelerated follicle apoptosis. Natural conception is infrequent, with only 5.6% of a series of 500 women with TS conceiving spontaneously. Moreover, miscarriage rates are twice as high as in the general population. [...]
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Citations
Donnez, J., & Dolmans, M.-M. (2023). Fertility preservation in Turner girls: to do or not to do? Fertility and sterility, 120(5), 993-994. https://doi.org/10.1016/j.fertnstert.2023.08.971 (Original work published 2023)