Isochrysis zhanjiangensis exhibits protective effects against metabolic abnormalities induced by high-fat diet in mice
(2025) Marine Life Science & Technology — Vol. 7, n° 10, p. 1-20 (2025)
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- Abstract
- While Isochrysis zhanjiangensis, a marine microalga, has been widely adopted in aquaculture for its health-promoting properties, its potential as a functional food for human metabolic health remains unexplored. To bridge this gap, this study systematically evaluated the nutritional composition, biosafety, and therapeutic efficacy of I. zhanjiangensis against high-fat diet (HFD)-induced metabolic disorders in mice. Our results revealed that I. zhanjiangensis exhibits a desirable nutritional profile with no detectable toxicity, and its dietary supplementation significantly attenuated HFD-induced metabolic dysregulation. Gut microbiota profiling further demonstrated that I. zhanjiangensis supplementation restored microbial homeostasis, evidenced by mitigation of the elevated Firmicutes/Bacteroidota ratio and enrichment of beneficial genera including Muribaculum, Candidatus_Arthromitus, and Veillonella. Hepatic metabolomics identified key metabolites modulated by I. zhanjiangensis, such as N1-methyl-2-pyridone-5-carboxamide, N-acetyl-L-histidine, and eicosapentaenoic acid, which are mechanistically linked to lipid metabolism regulation. These findings not only position I. zhanjiangensis as a promising candidate for functional food development targeting HFD-induced metabolic dysregulation, but also highlight the untapped potential of aquaculture microalgae as sustainable resources for nutraceutical innovation.
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Wu, M., Bai, Y., Li, Y., Chen, K., Le, J., Li, J., Zhou, C., Agathos, S. N., Zhang, L., Yan, X., & Han, J. (2025). Isochrysis zhanjiangensis exhibits protective effects against metabolic abnormalities induced by high-fat diet in mice. Marine Life Science & Technology, 7(10), 1-20. https://doi.org/10.1007/s42995-025-00320-x (Original work published 2025)