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Observations from real-world problems are often high-dimensional vectors, i.e. made up of many variables. Learning methods, including artificial neural networks, often have difficulties to handle a relatively small number of high-dimensional data. In this paper, we show how concepts gained from our intuition on 2- and 3-dimensional data can be misleading when used in high-dimensional settings. When then show how the "curse of dimensionality" and the "empty space phenomenon" can be taken into account in the design of neural network algorithms, and how non-linear dimension reduction techniques can be used to circumvent the problem. We conclude by an illustrative example of this last method on the forecasting of financial time series.