We introduce a disruptive ultra-low-leakage design technique, based on a pair of source-connected n- and p-MOSFETs, auto-biasing the stand-by gate-to-source voltage of the nMOSFET at negative voltage and that of the p-device at positive, thereby pushing the off current of analog and digital functions towards its physical limits, without reducing functional performance. Therefrom, we designed ultra-low-power basic blocks (2-terminal diode, 3-terminal transistor, voltage follower), circuits (7-transistor SRAM and MTCMOS latch with record low leakage but still high speed), as well as microsystems (e.g. high-frequency power-management units for RF and PV energy harvesting and micro<att interface for implanted capacitive sensors).