DNA Detection Based on Capacitive Al/Al2O3 Microelectrodes
(2004) 17th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2004) — Location: Maastricht (the Netherlands) (25.January.2004)
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- Abstract
- The electrical detection of DNA hybridization still faces the challenge of detecting very low concentrations. In this work we present the possibility of detecting DNA probes by measuring a capacitance change between interdigitated aluminum micro-fingers coated with a thin alumina layer and constructed over an oxidized silicon wafer. DNA Labeling was performed by biotinylated nucleotides and reaction with anti-biotin/gold nanoparticles, increased in size by silver crystal precipitation. The capacitance change ratio observed was at least of two, using 0.2 nM DNA solutions. This detection method appears compatible with microarray technology and paves the way for further use in biological applications.
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Moreno Hagelsieb, L., Lobert, P. E., Pampin, R., Remacle, J., & Flandre, D. (2004). DNA Detection Based on Capacitive Al/Al2O3 Microelectrodes. Proceedings of the 17th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2004), 308-311. https://doi.org/10.1109/MEMS.2004.1290584