Porcine pancreatic islets: from in vitro characterization to preclinical transplantation
(2023) European journal of transplantation — Vol. 1, n° Suppl 3, p. 226-233 (2023)
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- Authors
Gianello, Pierre 
- Abstract
- Porcine pancreatic islets could be used in the clinic as an alternative source of insulin-secreting cells in light of insufficient numbers of human pancreas donors. Prerequisites for clinical application include thorough understanding of porcine islet physiology as well as robust experimental in vivo trials using relevant models and permitting easy translation to humans. In vitro evaluation of pig islet secretory function and its comparison to that of human islets permit necessary adjustment of islet dose to be implanted, better choice of donor age and genetics, better understanding of treatment outcome and can serve as a basis for eventual modifications to boost function and survival. In vivo studies using the pig-to-non-human primate model are crucial to evaluate efficacy, safety and longevity of islet grafts. On the recipient side, refinement of immunosuppressive regimens and selection of an appropriate implantation site for free or encapsulated islets are equally important to promote diabetes reversal by the treatment and necessitate in vivo testing before application in humans.
- Affiliations
Citations
Mourad, N., & Gianello, P. (2023). Porcine pancreatic islets: from in vitro characterization to preclinical transplantation. European journal of transplantation, 1(Suppl 3), 226-233. https://doi.org/10.57603/ejt-275 (Original work published 2023)