Screening for Alzheimer's pathology in the elderly population : focus on spatial navigation

Colmant, Lise
(2025)

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Authors
Supervisors
Hanseeuw, Bernard
 ;
Lefèvre, Philippe
Abstract
Diagnosing Alzheimer’s Disease (AD) at an early stage, with non-invasive and costless tests, is crucial to develop new treatments which could be administered before cognitive deficits. In this thesis, we showed that older individuals at risk to AD and with a preclinical AD have difficulties orienting themselves in an environment without external cues. Furthermore, we showed that age impaired the appropriate use of a landmark. Then, we demonstrated that the rotation error was specifically related to the tau level in the medial temporal lobe. Next, we determined the plasma Aβ42/Aβ40 threshold suggesting AD. Finally, we showed that combining plasma ptau181 with the performance in spatial orientation in an environment without external cues allows detecting individuals with a preclinical AD, at risk to develop cognitive impairment.
Affiliations
  • Institution iconUCLouvainSSS/IONS/NEUR - Clinical Neuroscience
  • Institution iconUCLouvainSST/ICTM/INMA - Pôle en ingénierie mathématique

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Colmant, L. (2025). Screening for Alzheimer’s pathology in the elderly population : focus on spatial navigation. https://hdl.handle.net/2078.5/242372