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HaxheJHepatol2024.pdf
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DESCRIPTION: A 36-year-old Hispanic woman was admitted to the emergency department with jaundice, abdominal pain and fatigue. The patient reported daily alcohol consumption (70 units per week). Physical examination revealed jaundice, hepatosplenomegaly, high BMI (30 kg/m2) and significant bilateral oedema of the lower limbs. Complete blood count showed a severe leucocytosis with neutrophilia (white blood cell count at 48,000/μl including 85% neutrophils) associated with bicytopenia (haemoglobin at 4.3 g/dl and platelet count at 87,000/μl). Liver tests indicated cholestasis (gamma-glutamyltransferase 573 U/L [<60 U/L] and alkaline phosphatase 300 U/L [40-130 U/L]) with total bilirubin of 11.6 mg/dl (direct 9.6 mg/dl [<1.2 mg/dl]), aspartate aminotransferase of 75 U/L [13-35 U/L], normal alanine aminotransferase and low albumin of 26 g/L [34-52 g/L]. C-reactive protein was elevated at 143 mg/L [<5 mg/dl]. [...]
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Haxhe, S., Baldin, P., Trefois, P., Havelange, V., & Lanthier, N. (2024). Jaundice with severe leucocytosis. Journal of Hepatology, 80(3), e103-e105. https://doi.org/10.1016/j.jhep.2023.10.014 (Original work published 2024)