One‐Carbon Homologation of α,β‐Unsaturated Aldehydes: Access to α‐Tertiary β,γ‐Unsaturated Aldehydes

Delbrassinne, Arnaud;Takam Mba, Boris Junior;Collard, Laurent;Robiette, Raphaël
(2023) European Journal of Organic Chemistry — Vol. 26, n° 40, p. e2023007 (2023)

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Abstract
An efficient two-step no purification protocol for the synthesis of enolizable α-subtituted β,γ-unsaturated aldehydes is reported. The developed strategy involves two steps, epoxidation and Meinwald rearrangement, to result in a formal one-carbon homologation of α,β-unsaturated aldehydes enabling the insertion of a CHR unit.
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Delbrassinne, A., Takam Mba, B. J., Collard, L., & Robiette, R. (2023). One‐Carbon Homologation of α,β‐Unsaturated Aldehydes: Access to α‐Tertiary β,γ‐Unsaturated Aldehydes. European Journal of Organic Chemistry, 26(40), e2023007. https://doi.org/10.1002/ejoc.202300765 (Original work published 2023)