Gut Microbiota and Metabolism
(2024) The Gut-Brain Axis : Dietary, Probiotic, and Prebiotic Interventions on the Microbiota — ISBN: [9780323999717], p. 145-159, published
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- Abstract
- Experimental data in animals, and also observational studies in obese patients, suggest that the composition and the functional properties of the gut microbiota differ in obese v. lean individuals, in diabetic v. non-diabetic patients and in patients presenting with other diseases associated with obesity or nutritional dysbalance, such as non-alcoholic steatohepatitis. Certain keystone species with significant metabolic importance can be under-represented in hosts exhibiting metabolic dysfunction. In addition, it is now apparent that the production of specific metabolites such as short chain fatty acids, amino-acid derived metabolites, or bile acids are modified and could have significant implications for metabolic function through direct action on a range of biological systems. This chapter will describe how changes in the gut microbiota composition and function modulate host metabolism. We have evaluated the potential relevance of microbiota-modifying therapeutics, such as prebiotics and probiotics, in the management of obesity and associated metabolic disturbances, in view of the experimental data and intervention studies published up to date.
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Delzenne, N., Rodriguez, J., & Neyrinck, A. (2024). Gut Microbiota and Metabolism. In Niall Hyland and Catherine Stanton (ed.), The Gut-Brain Axis : Dietary, Probiotic, and Prebiotic Interventions on the Microbiota (2nd edition, p. p. 145-159). Elsevier. https://doi.org/10.1016/b978-0-323-99971-7.00015-1